Feeling rough? 10 tips for getting through common side effects
Robert Price | Last update: 7th October 2025
From nausea to fatigue, and a few things in between, drugs like Mounjaro and Wegovy are not always without someside effects. Fortunately, these are usually manageable with the right strategies. Here are 10 SlimrChat tips to help you navigate through
*Laura, a director in the NHS had a fantastic first fortnight on the weight loss drugs. Reduced appetite, food noise gone, and a 12lb weight loss. But into the next fortnight, she noticed her urge to go to the loo had almost gone, and realised she was extremely constipated..
“I’m not very regular at the best of times,” she told SlimrChat. “But this was another level. It was days and days of being bloated and uncomfortable; before I realised I’d underestimated how much fluid I actually needed to combat the new way my body was working on the drugs.”
Constipation, fatigue, heartburn…there are a number of issues our community has suffered. But fortunately, not everyone experiences side effects, and for most, they are temporary and manageable.
1. Follow the correct dosage plan
Starting with a lower dose and gradually increasing helps your body adjust to the treatment. You must always follow the instructions and advice given regarding weight loss treatments. Ensure you consult with your doctor or healthcare provider if you have any queries.
2. Eat smaller, more frequent meals
Large meals can exacerbate nausea or feelings of fullness. Opt for smaller portions spread throughout the day to reduce discomfort. Choose nutrient-dense, easy-to-digest foods like bananas, rice, or oatmeal when feeling unwell.
Want to reduce bloating? Have a look at Easing the discomfort.
3. Stay hydrated
Dehydration can worsen side effects like headaches or dizziness. The Eatwell Guide, adopted by the NHS (NHS website), recommends 2-3 litres of water per day to stay hydrated and energised. Sip on water or herbal teas throughout the day rather than drinking large amounts at once.
4. Avoid greasy or spicy foods
it might be time to wave goodbye to the madras. Foods that are heavy or overly spicy can trigger nausea and stomach upset. So if your stomach feels sensitive, stick to mild foods. Keep a food diary to identify which foods agree with you and which ones don’t.
5. Time your doses wisely
Taking your medication at a time that aligns with your schedule can make a big difference. Many find that taking weight loss drugs treatments in the evening reduces daytime side effects.
For more advice on managing your doses have a look at Choosing your injection time and day to minimise side effects.
6. Stay active
Gentle movement like walking or yoga can help alleviate bloating or stomach discomfort. Physical activity also boosts energy levels, countering fatigue. Aim for a short walk after meals to aid digestion and minimise side effects.
7. Manage nausea with ginger or peppermint
Natural remedies like ginger tea or peppermint oil can help soothe nausea. Keep these handy for when queasiness strikes.
Have a read of Beating nausea to find out more
8. Prioritise sleep
Fatigue is a common side effect, especially when starting treatment. Ensure you’re getting 7-9 hours of quality sleep each night to allow your body to adjust. We recommend establishing a calming bedtime routine, like reading or meditating, to improve sleep quality. Magnesium is a favoured supplement for the SlimrChat community.
Want to know more about beating tiredness? Read How to fight tiredness.
9. Address constipation proactively
Like *Laura you might find constipation is a side effect of GLP-1 treatments. Increase your fibre intake with foods like vegetables, whole grains, and legumes, and drink plenty of water. Maybe consider adding a fibre supplement or probiotics to your routine for added support.
More practical tips to solve constipation – Practical solutions for relief.
10. Communicate with your healthcare provider
If side effects persist or worsen, don’t hesitate to reach out to your doctor, or healthcare provider. They can adjust your dosage, recommend additional strategies, or explore alternative treatments. Be sure to keep a log of your symptoms to share with your doctor, helping them tailor advice to your experience.
Have your own tips for managing side effects? Share them with the SlimrChat community and learn from others navigating the same journey. Together, we can make the process smoother and more successful.