Feeling tired on weight loss drugs? It might be your diet
Robert Price | Last update: 1st May 2025
Wegovy and Mounjaro, are powerful tools for managing your weight, but experiencing constant fatigue while using them could signal deeper issues. While tiredness might be a side effect of the medication, certain diets can worsen energy depletion and slow progress.

Carbs are essential
Carbohydrates often get a bad reputation in weight loss circles, but they are the body and brain’s preferred fuel source. Drastically cutting them can exacerbate low blood sugar risks associated with weight loss drugs, further intensifying fatigue.
The takeaway? Balance is key. To maintain steady energy levels, opt for slow-releasing carbs like oats, quinoa, and sweet potatoes.
Fasting is NOT necessary
Intermittent fasting has become a popular trend, but extending fasting periods while on weight loss drugs can leave you irritable, exhausted, and prone to energy crashes.
During your natural overnight fast, your body already undergoes fat-burning and cellular repair. Prolonging fasting periods may amplify fatigue, especially if your appetite is suppressed.
Instead, prioritise regular meal patterns with small, balanced meals throughout the day.
Too few calories cause problems
Weight loss drugs are known for suppressing appetite, making it easy to undereat without realising it. However, extremely low-calorie diets can increase muscle loss, sap energy levels, and harm metabolism in the long run.
It’s essential to recognise that quality matters just as much as quantity. Lean proteins, healthy fats, and fibre-rich foods keep you fuller for longer and help stabilise blood sugar. Incorporating nutrient-dense snacks like nuts, Greek yoghurt, and boiled eggs can prevent dips in energy. Here’s some more diet tips from SlimrChat.
Listen to your body
Fatigue might also signal that your body needs more than just food — it could be dehydration, a vitamin deficiency, or even inadequate sleep. Many SlimrChat members report that paying attention to their hydration levels and ensuring proper vitamin intake made a noticeable difference in their energy.
If fatigue persists despite dietary adjustments, it’s worth consulting your doctor. Simple blood tests can uncover deficiencies like iron or B12, which are common causes of tiredness.
It’s about sustainable weight loss
Sustainable weight loss with weight loss drugs isn’t about quick fixes or extreme diets. Instead, it’s about finding a balance — nourishing the body adequately with carbohydrates, maintaining regular meal patterns, and ensuring sufficient calorie intake to preserve muscle and energy.
It is crucial to build habits that support long-term success. Combining nutrition with light activity, such as walking or yoga, can also boost energy and improve overall well-being without adding stress to the body.
Tips for avoiding tiredness
- Include complex carbohydrates: Aim for whole grains, fruits, and vegetables to keep energy stable.
- Space meals evenly through your day: Avoid extended fasting and prioritise balanced meals timed evenly over the day.
- Monitor your calorie intake: Don’t let appetite suppression lead to undereating; track portions to ensure adequate nutrition.
- Stay hydrated: Dehydration can mimic fatigue, so drink plenty of water.
- Supplement your diet smartly: Consider vitamins or minerals like iron and B12 if necessary, but consult your doctor first.
- Incorporate light exercise: Gentle activities like walking or yoga can improve circulation and boost energy.
- Get enough sleep: Prioritise rest to support your body’s recovery and energy levels.
Have you faced fatigue while using weight loss drugs? What changes helped you feel more energised? Help the community by starting a chat. Or get tips by reading some chats.